Topic: Ludwig Maximilians University

ACE Inhibitor/ARB Combination Worsens Major Renal Outcomes

Modern Medicine - 1277 days ago
The combined use of the angiotensin converting enzyme (ACE) inhibitor ramipril and the angiotensin receptor blocker (ARB) telmisartan in patients with high cardiovascular risk is associated with worsened major renal outcomes compared to these drugs as monotherapy, researchers report in the Aug ...

Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase

Science - 1558 days ago
DNA polymerase (Pol ) is a eukaryotic lesion bypass polymerase that helps organisms to survive exposure to ultraviolet (UV) radiation, and tumor cells to gain resistance against cisplatin-based chemotherapy. The damaged DNA is bound in an open DNA binding rim. Nucleotidyl transfer requires ...